eISSN 2508-3589
pISSN 2508-1926

Table. 1.

Table. 1.

Criteria for intravitreal aflibercept injection interval in the treat-and-extend regimen

Criteria for the injection interval
Criteria for shortening the injection interval
Any of following
• The presence of new IRF or SRF on OCT
• The presence of persistent IRF or SRF with increased fluid on OCT
• The presence of persistent IRF with unchanged fluid on OCT
• Loss of BCVA from the previous visit in conjunction with recurrent fluid on OCT
• Increased on CMT measured by OCT
• New neovascularization
• New macular hemorrhage
Criteria for maintaining the injection interval
Any of following
• The presence of persistent IRF or SRF with decreased fluid on OCT
• The presence of persistent SRF with unchanged fluid on OCT
And
• No loss of BCVA from the previous visit
• No new neovascularization
• No new macular hemorrhage
Criteria for extending the injection interval
• If none of the criteria for shortening were met and there was no fluid on OCT, the injection interval was extended

IRF = intraretinal fluid; SRF = subretinal fluid; OCT = optical coherence tomography; BCVA = best-corrected visual acuity; CMT = central macular thickness.

J Retin 2021;6:99-109 https://doi.org/10.21561/jor.2021.6.2.99
© 2021 J Retin