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Diurnal Variation of the Choroid in Normal Korean Subjects
Journal of Retina 2018;3(2):76-81
Published online November 30, 2018
© 2018 The Korean Retina Society.

San Seong, Yang Jae Kim, Ju Young Kim, Jin Hae Lee, Hyun Sup Oh, Soon Hyun Kim, Oh Woong Kwon, Yong Sung You

Retina Center, Nune Eye Hospital, Seoul, Korea
Correspondence to: Sung You, MD, PhD
Department of Ophthalmology, Nune Eye Hospital, #404 Seolleung-ro, Gangnam-Gu, Seoul 06198, Korea
Tel: +82-2-2086-7752, Fax: +82-2-2086-7779
Received August 6, 2018; Revised August 21, 2018; Accepted August 23, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: To determine the diurnal variation in choroidal thickness and choriocapillaris flow measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)
Methods: This study was a prospective study of 15 normal, young volunteers (30 eyes) who underwent OCT and OCTA examination 5 times a day at 2-hour intervals. Choroidal and choriocapillaris thicknesses were measured with the enhanced depth imaging mode of OCT. The area of flow was measured in 1-, 3-, and 6-mm-diameter areas centered at the fovea and analyzed with the split-spectrum amplitude-decorrelation angiography algorithm of OCTA. Choroidal and choriocapillaris thicknesses and flows were analyzed independently by two vitreoretinal specialists.
Results: Choroidal thickness showed a significant diurnal variation. The maximum thickness was 311.31 μm at 9 a.m., and the minimum thickness was 266.75 μm at 5 p.m. (p < 0.001). In contrast, the mean choriocapillaris thickness was 15.14 μm, and remained relatively constant without a significant diurnal variation (p = 0.694). The mean choriocapillaris flow area was 0.45 mm2 (p = 0.238) in a 1 mm area, 4.22 mm2 (p = 0.230) in a 3-mm diameter area, and 16.94 mm2 (p = 0.062) in a 6-mm diameter area. No diurnal variation was observed.
Conclusions: Despite significant diurnal variation in choroidal thickness, choriocapillaris thickness and flow remained relatively constant over time.
Keywords : Choriocapillaris; Optical coherence tomography; Optical coherence tomography angiography

November 2018, 3 (2)
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