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Fig. 1.

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Fig. 1. Clinical course of a 69-year-old patient diagnosed with neovascular age-related macular degeneration in the right eye. At diagnosis, a blot retinal hemorrhage accompanied with drusen and pseudodrusen was noted on fundus photography (A). On fluorescein angiography, active leakage was noted (B). On optical coherence tomography (OCT), intraretinal fluid, subretinal fluid, and retinal pigment epithelial detachment was noted (C). On OCT image scanning inferior to the fovea, an intraretinal hyperreflective lesion accompanied by surrounding intraretinal edema and disruption of retinal pigment epithelium was observed (arrow) (D), suggesting that the lesion represented a retinal angiomatous proliferation. The patient was treated with three monthly ranibizumab injections. After treatment, all fluid was completely resolved (E). Re-treatment was performed using an as-needed regimen and the first recurrence was noted 4 months after the third injection (F). The as-needed regimen was continued for 32 months. At 32 months, no fluid was observed on OCT (G). However, to minimize further damage to the retina, the treatment regimen was switched to treatand- extend (TAE). OCT images taken at 12 months (H) after switching to TAE showed a dry retina. At 26 months, a small amount of intraretinal fluid was noted (arrow) (I), but this resolved after additional treatment. At 31 months, the best-corrected visual acuity was 0.2. Retinal pigment epithelial atrophy was also noted (dotted circle) (J). The blue and yellow lines in panel (A) indicate the OCT scanning lines for panels (C, D) respectively.
J Retin 2021;6:155-61 https://doi.org/10.21561/jor.2021.6.2.155
© 2021 J Retin