eISSN 2508-3589
pISSN 2508-1926

Table. 2.

Table. 2.

Mean spherical equivalent baseline and differences of average ChT and average ONL in the eyes of the groups

Variable No Retinopathy, HCQ Continued (A) (n = 49) No Retinopathy, HCQ Discontinued (B) (n = 9) HCQ Retinopathy (C) (n = 9) Normal (n = 35) Multiple Comparison (p-value)
Spherical equivalent -1.07 ± 0.16 -0.68 ± 0.44 -1.54 ± 0.36 -1.05 ± 0.35 NS
Baseline Avg ChT 227.15 ± 11.46 212.33 ± 19.01 171.04 ± 27.35 238.41 ± 5.81 C vs. normal: 0.009*
Last Avg ChT 205.77 ± 8.82 225.04 ± 19.67 167.74 ± 27.40 234.79 ± 12.70 B vs. C: 0.047*
C vs. normal: 0.009*
ΔAvg ChT -21.38 ± 4.33 12.70 ± 5.08 -3.29 ± 3.97 -3.61 ± 3.15 A vs. B: < 0.001*
A vs. C: 0.025*
A vs. normal: 0.003*
B vs. C: 0.015*
B vs. normal: 0.018*
Baseline Avg ONL (ETDRS inner) 66.49 ± 1.43 63.22 ± 2.54 54.22 ± 3.58 66.87 ± 1.34 A vs. C: 0.004*
C vs. normal: 0.002*
Last Avg ONL (ETDRS inner) 65.48 ± 1.52 62.34 ± 2.15 50.61 ± 3.47 66.96 ± 1.45 A vs. C: 0.001*
B vs. C: 0.015*
C vs. normal: < 0.001*
Baseline Avg ONL (ETDRS outer) 54.08 ± 1.26 50.81 ± 2.52 33.31 ± 2.61 53.41 ± 1.02 A vs. C: <0.001*
B vs. C: 0.001*
C vs. normal: <0.001*
Last Avg ONL (ETDRS outer) 52.56 ± 1.36 49.28 ± 2.26 31.33 ± 2.57 53.26 ± 0.99 A vs. C: <0.001*
B vs. C: 0.002*
C vs. normal: <0.001*
ΔAvg ONL ETDRS inner -1.01 ± 0.65 -0.86 ± 1.06 -3.61 ± 1.85 0.09 ± 0.73 NS
ΔAvg ONL ETDRS outer -1.52 ± 0.51 -1.53 ± 0.54 -1.97 ± 1.16 -0.14 ± 0.36 A vs. normal: 0.045*
B vs. normal: 0.032*

Values are presented as mean ± standard deviatioin.

ChT = choroidal thickness; ONL = outer nuclear layer; HCQ = hydroxychloroquine; NS = no significant in between-group analysis;

Avg = average; ETDRS = Early Treatment of Diabetic Retinopathy Study.

*Significant p-value: p ≤ 0.05, Mann-Whitney test (A vs. B, A vs. C, B vs. C, B vs. normal, C vs. normal), t-test (A vs. normal).
J Retin 2024;9:62-72 https://doi.org/10.21561/jor.2024.9.1.62
© 2024 J Retin