The images of the 11-year-old boy with autosomal-dominant RHO, D190N retinitis pigmentosa. (A, B) Autofluorescence (AF) image of the right macula exhibiting a hyperautofluorescent ring around the fovea. Dotted squares represent corresponding areas of adaptive-optics scanning laser ophthalmoscope imaging (AO-SLO) (E). Yellow arrowheads mark disruption to the inner segment ellipsoid band as detected by spectral-domain optical coherence tomography (OCT). (C) Microperimetry mapping reveals a decline in visual sensitivity (dB) across the hyperautofluorescent ring but no loss in sensitivity in areas within the ring. (D) A plot of photoreceptor outer segment and retinal pigment epithelial thickness across the fovea and retinal thickness in the same area within the ring, showing abrupt thinning beyond the borders of the ring. (E) AO-SLO images taken at positions 0.5, 1.0, and 1.5 mm (temporally and nasally) from the fovea. Corresponding areas are mapped to a 30° AF image (A). Many cones were not individually discernible and appeared misshapen in comparison to those of normal subjects. Overall spacing between individual cones also appeared to increase (white arrowheads). (F) AO-SLO images taken within the same retinal positions in an age-matched healthy subject. The cone mosaic in normal subjects appeared as a densely packed, well-ordered matrix. Adapted from the article of Park et al [43].